Intratumor heterogeneity: seeing the wood for the trees.

صدمات فیزیکی و ریالی به درختان مقطوعه در عملیات قطع (مطالعه موردی: جنگل‌های حوزه آبخیز اسالم)

Awareness of quality and quantity of wood produced in forestry plans play an important role in management of this product in market. The objective of this study that has been carried out in 7th watershed of north forest of Iran was to determine effective factors on wood breakage in felled trees, compare wood losses during felling and identify wood losses in felled trees and methods of their pre...

Seeing the wood for the trees.

Discovering intratumor heterogeneity: the next frontier for pathologists.

Discovering intratumor heterogeneity is a crucial issue in modern oncologic medicine. Highly sophisticated technology such as high-throughput DNA sequencing has demonstrated the real dimension of the problem. The overwhelming majority of malignant tumors show high levels of intratumor heterogeneity when thoroughly studied. Intratumor heterogeneity develops both in temporal and spatial domains a...

Hypermutable DNA chronicles the evolution of human colon cancer.

Intratumor genetic heterogeneity reflects the evolutionary history of a cancer and is thought to influence treatment outcomes. Here we report that a simple PCR-based assay interrogating somatic variation in hypermutable polyguanine (poly-G) repeats can provide a rapid and reliable assessment of mitotic history and clonal architecture in human cancer. We use poly-G repeat genotyping to study the...

Words of wisdom. Re: Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

BACKGROUND Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples. METHODS To examine intratumor heterogeneity, we performed exome sequencing, chromosome aberration analysis, and ploidy profiling on multiple spatially separated samples obtained from primary renal carcinomas and asso...